Whole genome sequence differences between somatic and cancerous cells

A recent paper in Nature has reported a study that I've been waiting to see for so long. They took two cell lines from a single individual - one cultured from normal somatic tissue and the other cultured from a tumour - and aligned the whole genome sequences.

They found some mutations in genes that have been previously identified as candidates for cancer phenotypes, but what's interesting is how the advancement of technology just multiplies the complexity of the problem!

Many issues are likely to confound these types of studies:

Nonetheless, overcoming these problems and implementing on a larger scale will probably be very illuminating.

Typing and design by Gib Hemani

2010-02-19 17:36:12

| Science |